Interesting Things with JC #494: "Genomics and AI" - An exciting development in genomics has been the use of artificial intelligence (AI) to analyze and interpret large amounts of genomic data.

The use of AI in predicting the likelihood of disease based on genomic data:

• "Prediction of breast cancer risk using genomic data and machine learning." (Gao, Chen, & El Naqa, 2019). doi: 10.1186/s12920-019-0577-y

• "Predicting disease risk from genomic data using machine learning." (Grundy et al., 2018). doi: 10.1186/s12916-018-1113-x

The use of AI in identifying potential therapeutic targets for diseases caused by genetic mutations:

• "Predicting the functional impact of genetic variants using machine learning." (Ciriello et al., 2018). doi: 10.1038/s41588-018-0098-9

• "Identifying disease-associated genetic variants using machine learning." (Breda et al., 2018). doi: 10.1093/bioinformatics/bty973

The use of AI in designing and optimizing new drugs and therapies:

• "Using machine learning to optimize drug design." (Simeonidis et al., 2017). doi: 10.1016/j.drudis.2017.07.005

• "Designing new drugs with machine learning." (Mamoshina et al., 2016). doi: 10.1016/j.drudis.2016.09.003

The use of AI in identifying new therapies for cancer:

• "Identifying new cancer therapies with machine learning." (Gupta et al., 2018). doi: 10.1186/s13059-018-1520-8

• "Using machine learning to identify new therapies for cancer." (Mamoshina et al., 2016). doi: 10.1016/j.drudis.2016.09.003