Interesting Things with JC #287: "Beefalo" is a cross between domestic cows and the North American Bison.A full- blood Beefalo does not contain less than 3/8 Bision. Beefalo was developed in the early 1970’s by a Californian producer who successfully interbreed American Bison with domesticated cattle. After nearly 150 years of selective breeding, the perfect balance was found. Please visit AmericanBeefaloAssociation.com for more information!